Navy Captain Tom Chandler and his crew (including 218 men and women) must find a way to save mankind from extinction after a lethal virus exterminates 80% of the world's population. Scientist Rachel Scott takes the mission to join U.S.S. Nathan James to research into the cause of the speedily spreading virus and create a cure. Chandler and his crew may be humanity's last hope in the wake of a worldwide devastating catastrophe.